Bcl-2 Pathway

B-cell lymphoma-2 (Bcl-2)-family proteins play an important role in regulating the induction of apoptosis. Based on their protein structure and function, the Bcl-2 family members can be further subdivided into three groups: the pro-apoptotic, anti-apoptotic, and BH3-only subfamilies. The pro-apoptotic Bax-like subfamily promotes apoptosis by forming pores in the mitochondrial outer membrane and regulating mitochondrial cytochrome C release, ultimately inducing cell death through the caspase cascade. Anti-apoptotic proteins, such as Bcl-2, contain a transmembrane Bcl-2 homology (BH) domain which mediates their localization to the mitochondrial membrane, where they inhibit apoptosis by interacting with and sequestering pro-apoptotic family members. The BH3-only subfamily is composed of proteins that share little sequence homology with other Bcl-2 family members except the BH3 domain. Many cellular signaling pathways including death receptors, growth factor receptors and DNA damage sensors converge on Bcl-2 family members to modulate the induction of apoptosis.

GeneTex is proud to introduce a comprehensive selection of high quality Bcl-2 family antibodies to enhance your research. In addition, our scientists have developed three Bcl-2 Family Sampler Kits with combinations of antibodies to Bcl-2 family proteins. These Bcl-2 Family Sampler Kits are convenient and efficient tools to study Bcl-2 family proteins and their role in apoptosis.